Indima kaI-Trimethylamine Hydrochloride (TMA Hcl)Kwi-carnitine kuxhomekeke ekusetyenzisweni kwayo njengezinto ezikrwada zekhemikhali (ezibonelela ngamaqela e-trimethylamine) ukwenza i-carnitine. Ngamafutshane, yenye "yeembombo" zokwenza i-carnitine.

Kwimveliso yemizi-mveliso, indlela yokwenziwa kwe-carnitine imalunga nolu hlobo lulandelayo:

·Nika isakhiwo esibalulekileyo:

I-TrimethylaminhydrochlorideIbonelela nge-trimethylamine kwi-reactants, eyinxalenye ebalulekileyo yesakhiwo se-quaternary ammonium kwiimolekyuli ze-carnitine.

·Inkqubo ethile yokwenziwa kwezinto:

Kwishishini, ukuqala kwi-epichlorohydrin,I-Trimethylamine Hydrochlorideyongezwa kwimpendulo ye-amination. Emva kwamanyathelo alandelayo afana ne-cyanide kunye ne-hydrolysis, i-carnitine ekugqibeleni ifunyenwe.

·Yenziwe ngohlobo lwetyuwa:

Ukuze kuphuculwe uzinzo kwaye kwandiswe ixesha lokugcinwa, i-carnitine edityanisiweyo idla ngokuphendulwa nge-hydrochloric acid ukuvelisa i-carnitine hydrochloride, ekulungeleyo ukugcinwa nokuthuthwa.

I-L-carnitineIsetyenziswa kakhulu njengesithambisi sesondlo kunye nesikhuthazi semetabolism yamandla ekutyeni.
Yi-amino acid ephuma kwindalo enokukhuphula ukubola kwamafutha kwizilwanyana kwaye iphucule ukusetyenziswa kwamandla. Ukongeza i-L-carnitine ekutyeni kunemisebenzi ebalulekileyo elandelayo:

1. Ukukhuthaza imetabolism yamafutha:

I-L-carnitine sisithwali esibalulekileyo se-long-chain fatty acids ukungena kwi-mitochondria ukuze kubekho i-β-oxidation, nto leyo enokuphucula kakhulu ukusetyenziswa kwamafutha ezilwanyana kwaye inciphise ukugcinwa kwamafutha emzimbeni.

2. Ukuphucula ukusebenza kokukhula:

Ngokuphucula imetabolism yamandla, izinga lokuguqulwa kokutya linokwandiswa, okukhuthaza ukwanda kobunzima bezilwanyana, ngakumbi ezifanelekileyo kwimfuyo nakwiinkukhu ngexesha lokutyeba. Uphando lubonise ukuba ukongeza i-50-100mg/kg ye-L-carnitine ekutyeni kweehagu kunokunyusa ukwanda kobunzima bemihla ngemihla nge-5-8%.

3. Ukuphucula ukusebenza kokuzala:

Ukuyifaka ekutyeni kwemfuyo kunokunyusa ukuhamba kwesidoda, izinga lokumitha, kunye nobukhulu beentsana. Umlinganiselo ocetyiswayo wokuzala kweenkunzi zehagu yi-100-150mg/kg.

4. Yonyusa ukumelana noxinzelelo:

Ingaphucula iingxaki zemetabolism yezilwanyana phantsi kweemeko zoxinzelelo ezifana nobushushu obuphezulu kunye nokuthuthwa, kwaye igcine imisebenzi eqhelekileyo yomzimba.

5. Phucula umgangatho wenyama:

ukunciphisa ukugcwala kwamafutha, ukwandisa umlinganiselo wemisipha, kunye nokuphucula umgangatho wenyama.

Amanyathelo okusebenzisa:
Umlinganiselo ofanelekileyo weentlobo ezahlukeneyo zezilwanyana kunye namanqanaba okukhula uyahluka kakhulu, kwaye kuyimfuneko ukulandela ngokungqongqo umlinganiselo ocetyiswayo.
Xa isetyenziswa kunye nee-antioxidants ezifana ne-vitamin E kunye ne-selenium, isiphumo siba ngconoXa ugcina, kuphephe iindawo ezinobushushu obuphezulu kunye nomswakama ophezuluXa kuxutywa ukutya, kuyimfuneko ukuqinisekisa ukuba kusasazeka ngokulinganayo