Ziziphi iimpembelelo ze-organic acids kunye ne-acidified glycerides "kwinkcaso engavumelekanga kunye nokunciphisa ukuxhathisa"?
Ukususela ekuvinjweni kweYurophu kubaxhasi bokukhula kwe-antibiotic (AGPs) kwi-2006, ukusetyenziswa kwee-acids eziphilayo kwisondlo sezilwanyana kuye kwabaluleka kakhulu kwishishini lokutya. Impembelelo yabo entle kumgangatho wokutya kunye nokusebenza kwezilwanyana sele ikhona amashumi eminyaka, njengoko besiya betsala umdla kushishino lokutya.
Yintoni iiasidi eziphilayo?
I-Organic acids" ibhekisa kuzo zonke iiasidi ezibizwa ngokuba zii-carboxylic acids ezakhelwe phezu kwekhabhon skeleton enokuguqula ubume bebhaktiriya, ibangele ukungahambi kakuhle kwemetabolism ethintela ukwanda kwaye ikhokelele ekufeni.
Phantse zonke iiasidi eziphilayo ezisetyenziswa kwisondlo sezilwanyana (ezifana ne-formic acid, i-propionic acid, i-lactic acid, i-acetic acid, i-sorbic acid okanye i-citric acid) inesakhiwo se-aliphatic kwaye yimithombo yamandla kwiiseli. Okuchasene,
benzoic acidyakhelwe kwimisesane enevumba elimnandi kwaye ineempawu ezahlukeneyo zemetabolism kunye nokufunxa.
Ukongezwa kwee-acids eziphilayo kwiidosi eziphezulu ngokufanelekileyo kwisondlo sezilwanyana kunokunyusa ubunzima bomzimba, ukuphucula ukuguqulwa kwesondlo kunye nokunciphisa ikholoni ye-pathogens emathunjini.
1, yehlisa ixabiso le-pH kunye nomthamo we-buffering kwi-feed kunye ne-antibacterial and antifungal effects.
I-2, ngokukhulula i-hydrogen ions esiswini ukunciphisa ixabiso le-pH, ngaloo ndlela isebenze i-pepsinogen ukwenza i-pepsin kunye nokuphucula i-protein digestibility;
3. Ukuvinjelwa kweebhaktheriya zegram-negative kwi-gastrointestinal tract.
I-4, i-metabolites ephakathi - isetyenziswe njengamandla.
Ukusebenza kwe-asidi ye-organic ekuvimbeleni ukukhula kwe-microbial kuxhomekeke kwixabiso layo le-pKa, elichaza i-pH ye-asidi kwi-50% kwifom yayo engadityaniswanga nengadityaniswanga. Le yokugqibela yindlela apho i-asidi ye-organic ineempawu ze-antimicrobial. Kuphela xa i-asidi ephilayo ikwimo yazo engadityaniswanga ukuba inokudlula kwiindonga zebhaktheriya kunye nefungi kwaye ziguqule imetabolism yazo ukuba zinamandla okulwa ne-antimicrobial. Ngaloo ndlela, oku kuthetha ukuba i-antimicrobial efficacy of organic acids iphezulu phantsi kweemeko ze-acidic (ezifana nesisu) kwaye iyancipha kwi-pH engathathi hlangothi (emathunjini).
Ngoko ke, i-organic acids enexabiso eliphezulu le-pKa i-acids ebuthakathaka kunye ne-antimicrobial esebenzayo kwisondlo ngenxa yobuninzi beefom ezingadibaniyo ezikhoyo kwisondlo, ezinokukhusela ukutya kwi-fungi kunye ne-microorganisms.
I-Acidified glyceride
Ngeminyaka yee-1980, isazinzulu saseMelika uAgre wafumanisa iprotein ye-cell membrane ebizwa ngokuba yi-aquaporin. Ukufunyanwa kwemijelo yamanzi kuvula indawo entsha yophando. Okwangoku, izazinzulu ziye zafumanisa ukuba i-aquaporins ikhona ngokubanzi kwizilwanyana, izityalo kunye ne-microorganisms.
Ngokudityaniswa kwe-propionic acid kunye ne-butyric acid kunye ne-glycerol, i-α-monopropionic acid glycerol ester, i-α-monobutyric acid glycerol ester, ngokuthintela iibhaktheriya kunye nomngundo wejeli ye-glycerol, iphazamise ukulungelelaniswa kwamandla kunye ne-membrane eguqukayo, ukwenzela ukuba balahlekelwe yimithombo yamandla, i-block energy synthesis kunye ne-bactericidus ye-drug synthesis ukuze badlale i-nobactericiduty effect.
Ixabiso le-pKa ye-organic acids yimpembelelo yabo yokuthintela kwii-microorganisms. Isenzo se-organic acids sihlala sixhomekeke kwi-dose, kwaye uninzi lwesithako esisebenzayo sifikelela kwindawo yesenzo, siphezulu isenzo esifunekayo. Oku kusebenza ngokubini kugcino lwesondlo kunye neziphumo zesondlo kunye nempilo kwizilwanyana. Ukuba kukho iiasidi ezinamandla, ityuwa ye-asidi ye-organic inganceda ukunciphisa amandla okuphazamisa ukutya kwaye inokubonelela nge-anions ukuveliswa kwe-organic acids.
I-Acidified glycerides enesakhiwo esikhethekileyo, i-α-monopropionate kunye ne-α-monobutyric glycerides, inefuthe elimangalisayo le-bactericidal kwi-Salmonella, i-Escherichia coli kunye nezinye iibhaktheriya zegram-negative kunye ne-clostridium ngokuthintela umjelo wamanzi-glycerine webhaktheriya, kwaye eli xabiso le-bactericidal alinqunyelwe yi-PH. Ayidlali indima kuphela emathunjini, kodwa kwakhona le glyceride ye-fatty chain short-chain ifunxelwa ngokuthe ngqo egazini ngokusebenzisa amathumbu, kwaye ifikelela kwiindawo ezahlukeneyo zomzimba ezichaphazelekayo nge-portal vein ukukhusela ngcono kunye nokulawula usulelo lwe-bacterial systemic.
Ixesha lokuposa: Aug-22-2024 
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