Zithini iziphumo ze-organic acids kunye ne-acidified glycerides "kwi-resistance engavumelekanga kunye ne-resistance enciphileyo"?
Ukususela ekuthintelweni kweYurophu kokukhuthaza ukukhula kwee-antibiotic (ii-AGP) ngo-2006, ukusetyenziswa kwee-organic acids kwisondlo sezilwanyana kuye kwaba yinto ebaluleke kakhulu kwishishini lokutya. Impembelelo yazo entle kumgangatho wokutya kunye nokusebenza kwezilwanyana ibikho kangangeminyaka emininzi, njengoko zitsala ingqalelo ngakumbi kwishishini lokutya.
Zithini ii-organic acids?
Ii-asidi ze-Organic" zibhekisa kuzo zonke ii-asidi ezibizwa ngokuba yi-carboxylic acids ezakhiwe kwi-carbon skeleton enokutshintsha ulwakhiwo lwebhaktheriya, ibangele iingxaki zemetabolism ezithintela ukwanda kwaye zikhokelele ekufeni.
Phantse zonke ii-asidi ze-organic ezisetyenziswa kwisondlo sezilwanyana (ezifana ne-formic acid, i-propionic acid, i-lactic acid, i-acetic acid, i-sorbic acid okanye i-citric acid) zinesakhiwo se-aliphatic kwaye ziyimithombo yamandla kwiiseli. Ngokwahlukileyo koko,
i-benzoic acidYakhelwe kwiindandatho zevumba elimnandi kwaye ineempawu ezahlukeneyo zemetabolism kunye nokufunxa.
Ukongezwa kwee-organic acids ngeedosi eziphezulu ezifanelekileyo ekutyeni kwezilwanyana kunokunyusa ubunzima bomzimba, kuphucule ukuguqulwa kokutya kwaye kunciphise ukungena kwezifo ezibangela izifo emathunjini.
1, kunciphisa ixabiso le-pH kunye nomthamo wokubopha kwisondlo kunye nemiphumo yokulwa neentsholongwane kunye nokubola.
2, ngokukhupha ii-ion ze-hydrogen esiswini ukunciphisa ixabiso le-pH, ngaloo ndlela kusebenze i-pepsinogen ukwenza i-pepsin nokuphucula ukugaywa kweproteni;
3. Ukuthintelwa kweentsholongwane ezingeyo gram kwindlela yokugaya ukutya.
4, ii-metabolites eziphakathi - zisetyenziswa njengamandla.
Ukusebenza kakuhle kwe-organic acid ekuthinteleni ukukhula kweentsholongwane kuxhomekeke kwixabiso layo le-pKa, elichaza i-pH ye-acid kwi-50% kwimo yayo ehlukanisiweyo nengahlukaniyo. Le yokugqibela yindlela ii-organic acids ezineempawu zokulwa nentsholongwane. Kuphela xa ii-organic acids zikwimo yazo engahlukaniyo apho zinokudlula kwiindonga zeebhaktheriya kunye nefungi kwaye zitshintshe imetabolism yazo apho zinamandla okulwa nentsholongwane. Ke ngoko, oku kuthetha ukuba ukusebenza kakuhle kwee-organic acids kuphezulu phantsi kweemeko ze-acid (ezifana nesisu) kwaye kunciphe kwi-pH engathathi cala (emathunjini).
Ngoko ke, ii-asidi ze-organic ezinexabiso eliphezulu le-pKa zii-asidi ezibuthathaka kwaye zisebenza ngakumbi ekulweni ngenxa yenani elikhulu leefom ezingadibaniyo ezikhoyo ekulweni, ezinokukhusela ukutya kwifungi nakwiintsholongwane.
I-glyceride ene-asidi
Kwiminyaka yoo-1980, isazinzulu saseMelika u-Agre safumanisa iproteni ye-membrane yeseli ebizwa ngokuba yi-aquaporin. Ukufunyanwa kwemijelo yamanzi kuvula indawo entsha yophando. Okwangoku, izazinzulu zifumanise ukuba ii-aquaporin zifumaneka kakhulu kwizilwanyana, kwizityalo nakwiintsholongwane.
Ngokudityaniswa kwe-propionic acid kunye ne-butyric acid kunye ne-glycerol, i-α-monopropionic acid glycerol ester, i-α-monobutyric acid glycerol ester, ngokuthintela itshaneli ye-glycerol yebhaktheriya kunye nefungi, iphazamisana nokulinganisela kwamandla kunye nebhalansi ye-membrane dynamic, ukuze ilahlekelwe yimithombo yamandla, ithintele ukuhlanganiswa kwamandla ukuze idlale isiphumo esihle se-bactericidal, kwaye kungabikho zintsalela zamayeza.
Ixabiso le-pKa lee-organic acids liyimpembelelo yazo yokuthintela iintsholongwane ezincinci. Isenzo see-organic acids sidla ngokuxhomekeka kumthamo, kwaye okukhona isithako esisebenzayo sifikelela kwindawo yokusebenza, kokukhona isenzo sifuneka kakhulu. Oku kusebenza kakuhle ekugcinweni kokutya kunye nemiphumo yesondlo kunye nempilo kwizilwanyana. Ukuba kukho ii-acids ezinamandla, ityuwa yee-organic acids inokunceda ukunciphisa amandla okugcina ukutya kwaye inokubonelela ngee-anions kwimveliso yee-organic acids.
Iiglycerides ezine-asidi ezinesakhiwo esahlukileyo, i-α-monopropionate kunye ne-α-monobutyric glycerides, zinefuthe elimangalisayo le-bactericidal kwiSalmonella, i-Escherichia coli kunye nezinye iibacteria ezine-gram-negative kunye ne-clostridium ngokuthintela i-water-glycerine channel yeebacteria, kwaye le mpembelelo ye-bactericidal ayithintelwanga lixabiso le-pKa kunye nexabiso le-PH; Ayidlali nje kuphela indima emathunjini, kodwa le short-chain fatty acid glyceride ifunxwa ngqo egazini ngamathumbu, kwaye ifikelela kwiindawo ezahlukeneyo zomzimba ezine-HIV nge-portal vein ukuze ithintele kwaye ilawule ngcono usulelo lwebhaktheriya oluqhelekileyo.
Ixesha lokuthumela: Agasti-22-2024 
2N`Q)59Z1G}VK.png)
