Kangangeminyaka emininzi i-butyric acid ibisetyenziswa kwishishini lokutya ukuphucula impilo yamathumbu kunye nokusebenza kwezilwanyana. Izizukulwana ezintsha ezininzi ziye zaziswa ukuphucula ukuphathwa kwemveliso kunye nokusebenza kwayo ukusukela oko kwenziwa uvavanyo lokuqala ngeminyaka yoo-1980.

Kangangeminyaka emininzi i-butyric acid ibisetyenziswa kwishishini lokutya ukuphucula impilo yamathumbu kunye nokusebenza kwezilwanyana. Izizukulwana ezintsha ezininzi ziye zaziswa ukuphucula ukuphathwa kwemveliso kunye nokusebenza kwayo ukusukela oko kwenziwa uvavanyo lokuqala ngeminyaka yoo-1980.

1 Uphuhliso lwe-butyric acid njengesongezelelo sesondlo

Kwiminyaka yoo-1980 > I-Butyric Acid esetyenziselwa ukuphucula uphuhliso lwesisu
Iityuwa ze-butyrin acid ezisetyenziselwa ukuphucula ukusebenza kwezilwanyana ngeminyaka yoo-1990
Kwiminyaka yoo-2000> iityuwa ezigqunyiweyo zaphuhliswa: ukufumaneka ngcono kwamathumbu kunye nevumba elincinci
Ngowama-2010> Kuveliswa i-asidi entsha ye-butyric eqinisekisiweyo nesebenza kakuhle

Namhlanje imakethi ilawulwa yi-butyric acid ekhuselweyo kakuhle. Abavelisi bokutya abasebenza ngezi zongezo abanangxaki ngeengxaki zevumba kwaye impembelelo yezongezo kwimpilo yamathumbu kunye nokusebenza kakuhle ingcono. Ingxaki ngeemveliso eziqhelekileyo ezigqunywe nge-coated nangona kunjalo, uxinzelelo oluphantsi lwe-butyric acid. Iityuwa ezigqunywe nge-coated zihlala ziqulathe i-25-30% ye-butyric acid, esezantsi kakhulu.

Uphuhliso lwamva nje kwi-additives zokutya ezisekelwe kwi-butyric acid kukuphuhliswa kwe-ProPhorce™ SR: ii-glycerol esters ze-butyric acid. Ezi triglycerides ze-butyric acid zinokufumaneka ngokwemvelo kubisi nobusi. Zezona ziphambili kakhulu kwi-butyric acid ekhuselweyo kunye noxinzelelo lwe-butyric acid ukuya kuthi ga kwi-85%. I-Glycerol inendawo yokuba neemolekyuli ezintathu ze-butyric acid ezinamathele kuyo ngokusebenzisa oko kubizwa ngokuba yi-'ester bonds'. Olu nxibelelwano lunamandla lukhona kuzo zonke ii-triglycerides kwaye lunokuphulwa kuphela zii-enzymes ezithile (lipase). Kwisivuno nasesiswini i-tributyrin ihlala injalo kwaye emathunjini apho i-pancreatic lipase ifumaneka khona ngokulula i-butyric acid iyakhutshwa.

Indlela yokwenza i-asidi ye-butyric ibonakale iyeyona ndlela isebenzayo yokwenza i-asidi ye-butyric engenavumba ekhutshwa apho uyifuna khona: emathunjini. Umahluko kwiityuwa ezigqunyiweyo udweliswe kumzobo wesi-2.

Kwi-ESPN yama-20 ePrague, uphando oluthelekisayo luboniswe ngesiphumo sezongezo ezimbini ezahlukeneyo ezisekelwe kwi-butyric acid kwiinkukhu zenyama. Olu vavanyo lwenziwe kwiziko lophando le-ADAS e-UK ngo-2014. Bathelekise ityuwa yesodium egqunywe nge-coating (ene-coating engama-68%) neProPhorce™ SR 130 (55% ye-butyric acid). Amantshontsho angama-720 eCoss308 ahlulwe ngamaqela ama-3, kunye neepeni ezili-12 zeentaka ezingama-20 kwiqela ngalinye. Ukulinganisa iimeko zorhwebo ngokusondeleyo kangangoko kunokwenzeka, inkunkuma engcolileyo yongezwa emva kovavanyo lwe-parasitological, bacterial kunye ne-viral pathology.

Umsebenzi weTributyrin

1. Ilungisa i-villi yamathumbu amancinci ezilwanyana kwaye ithintele iintsholongwane zamathumbu eziyingozi.

2.Iphucula ukufunxwa nokusetyenziswa kwezondlo.

3.Inganciphisa urhudo kunye noxinzelelo lokulunyulwa kwezilwanyana eziselula.

4. Yonyusa izinga lokusinda kunye nokwanda kobunzima bemihla ngemihla bezilwanyana eziselula.