I-Sodium Butyrate okanye i-tributyrin'okhetha yiphi'?

Kuyaziwa ngokubanzi ukuba i-butyric acid ngumthombo obalulekileyo wamandla kwiiseli zekoloni. Ngaphezu koko, ngokwenene ngumthombo wamafutha okhethwayo kwaye ubonelela ukuya kuthi ga kwi-70% yeemfuno zazo zamandla zizonke. Nangona kunjalo, kukho iindlela ezimbini onokukhetha kuzo. Eli nqaku libonelela ngothelekiso lwazo zombini, linceda ukuphendula umbuzo othi 'yeyiphi omawuyikhethe'?

Ukusetyenziswa kwe-butyrate njengesongezelelo sokondla kuye kwafundwa kakhulu kwaye kwasetyenziswa kwezolimo lwezilwanyana kangangeminyaka emininzi, kwaqala ukusetyenziswa kumathole ukukhuthaza uphuhliso lwesisu kwangethuba ngaphambi kokuba kusetyenziswe kwiihagu nakwiinkukhu.

Izongezo ze-butyrate zibonakalise ukuba ziphucula ukutyeba komzimba (BWG) kunye namazinga okuguqulwa kokutya (FCR), zinciphisa ukufa kwaye zinciphise impembelelo yezifo ezinxulumene namathumbu.

Imithombo eqhelekileyo ye-butyric acid yokutya kwezilwanyana iza ngeendlela ezimbini:

1. Njengetyuwa (umz. iSodium butyrate) okanye
2. Ngendlela ye-triglyceride (oko kukuthi i-Tributyrin).

Emva koko kuza umbuzo olandelayo –Ndikhetha eyiphi?Eli nqaku libonelela ngothelekiso olusecaleni kolunye.

Inkqubo yemveliso

I-sodium butyrate:Iveliswa nge-acid-base reaction ukuze yenze ityuwa eneqondo eliphezulu lokunyibilika.

I-NaOH+C4 H8 O2=C4 H7 COONa+H2O

(I-Sodium Hydroxide+I-Butyric Acid = I-Sodium Butyrate+Amanzi)

I-Tributyrin:Yenziwa nge-esterification apho i-3 butyric acid incamathiselwe kwi-glycerol ukuze yenze i-tributyrin. I-Tributyrin ineqondo lokunyibilika eliphantsi.

C3H8O3+3C4H8O2= C15 H26 O6+3H2O

(I-Glycerol+Butyric Acid = I-Tributyrin+Amanzi)

Yeyiphi enika i-butyric acid engaphezulu ngekhilogram yemveliso?

UkususelaItheyibhile 1, siyazi ubungakanani be-butyric acid ekwiimveliso ezahlukeneyo. Nangona kunjalo, kufuneka siqwalasele nendlela ezi mveliso ezikhupha ngayo i-butyric acid emathunjini ngempumelelo. Ekubeni i-sodium butyrate iyityuwa, iya kunyibilika lula emanzini ikhupha i-butyrate, ngoko ke singacinga ukuba i-100% ye-butyrate kwi-sodium butyrate iya kukhutshwa xa inyibilika. Njengoko i-sodium butyrate ihlukana lula, iifom ezikhuselweyo (oko kukuthi i-micro-encapsulation) ye-sodium butyrate ziya kuyinceda ifezekise ukukhululwa kancinci kwe-butyrate emathunjini ukuya kutsho kwi-colon.

I-Tributyrin ngokuyintloko yi-triacylglyceride (TAG), eyi-ester ephuma kwi-glycerol kunye nee-fatty acids ezi-3. I-Tributyrin ifuna i-lipase ukukhulula i-butyrate enamathele kwi-glycerol. Nangona i-tributyrin e-1 ine-butyrate ezi-3, ayizizo zonke i-butyrate ezi-3 eziqinisekisiweyo ukuba ziya kukhululwa. Oku kungenxa yokuba i-lipase ikhetha ngokwe-regioselective. Ingasusa i-triacylglycerides kwi-R1 kunye ne-R3, yi-R2 kuphela, okanye ingabi yiyo ngokukodwa. I-Lipase ikwanayo ne-substrate specificity kuba i-enzyme inokwahlula phakathi kwe-acyl chains enamathele kwi-glycerol kwaye ikhethe iintlobo ezithile. Ekubeni i-tributyrin ifuna i-lipase ukukhulula i-butyrate yayo, kunokubakho ukhuphiswano phakathi kwe-tributyrin kunye nezinye ii-TAG ze-lipase.

Ngaba i-sodium butyrate kunye ne-tributyrin ziyayichaphazela indlela umntu atya ngayo?

I-sodium butyrate inevumba elibi elingathandekiyo ebantwini kodwa elithandwa zizilwanyana ezanyisayo. I-sodium butyrate ibandakanya i-3.6-3.8% yamafutha obisi kubisi lwebele, ngoko ke, inokusebenza njengento etsala ukutya ebangela ukuba izilwanyana ezanyisayo ziphile ubomi obuqhelekileyo (Itheyibhile 2Nangona kunjalo, ukuqinisekisa ukukhululwa kancinci emathunjini, i-sodium butyrate idla ngokugqunywa nge-fat matrix coating (oko kukuthi i-Palm stearin). Oku kunceda ekunciphiseni ivumba elibi le-sodium butyrate.

Kwelinye icala, iTributyrin ayinavumba kodwa inencasa ebangela ukurhawuzelela (Itheyibhile 2). Ukongeza ubungakanani obukhulu kunokuba nemiphumo emibi ekutyeni ukutya. I-Tributyrin yimolekyuli ezinzileyo ngokwendalo enokudlula kwindlela ephezulu yesisu ide iqhekezwe yi-lipase emathunjini. Ayiguquguquki kubushushu begumbi, ngoko ke ayigqunywanga. I-Tributyrin idla ngokusebenzisa i-silica dioxide engangeniyo njengomthwali wayo. I-Silica dioxide inemibhobho kwaye isenokungayikhuphi ngokupheleleyo i-tributyrin ngexesha lokugaya. I-Tributyrin ikwanayo noxinzelelo lomphunga oluphezulu olubangela ukuba iguquguquke xa ishushu. Ke ngoko, sicebisa ukuba i-tributyrin isetyenziswe nokuba ikwimo ehlanganisiweyo okanye ikwimo ekhuselekileyo.