Isongezelelo sokutya: iTributyrin

Umxholo: 95%, 90%

I-Tributyrin njengesongezelelo sokondla iinkukhu ukuze kuphuculwe impilo yamathumbu.

Ukuyeka ukusebenzisa amayeza okubulala iintsholongwane njengezinto ezikhuthaza ukukhula kwiindlela zokupheka ukutya kweenkukhu kuye kwandisa umdla weendlela ezahlukeneyo zokutya, zombini ukwandisa ukusebenza kweenkukhu kunye nokukhusela kwiingxaki zezifo.

Ukunciphisa umngcipheko we-dysbacteriosis
Ukuze kujongwe iimeko ze-dysbacteriosis, izongezo zokutya ezifana neeprobiotics kunye neeprebiotics zongezwa ukuze zichaphazele ukuveliswa kwee-SCFAs, ngakumbi i-butyric acid edlala indima ephambili ekukhuseleni ukuqina kwendlela yamathumbu. I-butyric acid yi-SCFA yendalo eneziphumo ezininzi eziluncedo ezifana nesiphumo sayo sokulwa nokuvuvukala, impembelelo yayo ekukhawuleziseni inkqubo yokulungisa amathumbu kunye nokukhuthaza uphuhliso lwe-gut villi. Kukho indlela eyahlukileyo i-butyric acid esebenza ngayo ngendlela yokuthintela usulelo, oko kukuthi i-Host Defense Peptides (HDPs) synthesis, eyaziwa ngokuba zii-anti-microbial peptides, eziyinxalenye ebalulekileyo yokuzikhusela komzimba. Zine-broad-spectrum anti-microbial activity ngokuchasene neebhaktheriya, iifungi, iiparasite kunye neentsholongwane ezigqunywe yi-virus ezinzima kakhulu ukuba iintsholongwane zikwazi ukumelana nazo. I-Defensins (AvBD9 & AvBD14) kunye neCathelicidins ziintsapho ezimbini eziphambili ze-HDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) ezifumaneka kwinkukhu ezixhaswa yi-butyric acid supplementation. Kuphononongo olwenziwe nguSunkara et. al. Ukulawulwa kwe-butyric acid ngaphandle kwenza ukuba kubekho ukwanda okuphawulekayo kokubonakaliswa kwe-HDP gene kwaye ngaloo ndlela kuphucula amandla okumelana nezifo kwiinkukhu. Okunomdla kukuba, ii-LCFAs zincinci.

Iingenelo zempilo zeTributyrin
I-Tributyrin yi-precursor ye-butyric acid evumela iimolekyuli ezininzi ze-butyric acid ukuba zisiwe emathunjini amancinci ngokuthe ngqo ngenxa yendlela yokwenza i-esterification. Ngaloo ndlela, amazinga aphezulu kabini ukuya kathathu kuneemveliso eziqhelekileyo ezigqunywe nge-esterification. I-esterification ivumela iimolekyuli ezintathu ze-butyric acid ukuba zibotshelelwe kwi-glycerol enokwaphulwa kuphela yi-pancreatic lipase engapheliyo.
ULi et al. baqalise uphando lwe-immunological ukuze bafumane iziphumo eziluncedo ze-tributyrin kwi-cytokines ezibangela ukuvuvukala kwiinkukhu ezichatshazelwa yi-LPS (lipopolysaccharide). Ukusetyenziswa kwe-LPS kwaziwa ngokubanzi ukuba kubangela ukuvuvukala kwizifundo ezinje kuba kuvuselela iimpawu zokuvuvukala ezifana ne-IL (Interleukins). Kwiintsuku ezingama-22, 24, kunye ne-26 zovavanyo, iinkukhu ezisandul’ ukuzalwa zachatshazelwa ngokunikezelwa kwe-500 μg/kg ye-BW LPS okanye i-saline ngaphakathi kwesisu. Ukongezwa kwe-tributyrin yokutya kwe-500 mg/kg kwathintela ukunyuka kwe-IL-1β kunye ne-IL-6 nto leyo ebonisa ukuba ukongezwa kwayo kunakho ukunciphisa ukukhululwa kwee-cytokines ezibangela ukuvuvukala kwaye ngaloo ndlela kunciphise ukudumba kwamathumbu.

Isishwankathelo
Ngenxa yokusetyenziswa okulinganiselweyo okanye ukuvalwa ngokupheleleyo kwezinto ezithile ezikhuthaza ukukhula kwee-antibiotics njengezongezo zokutya, amaqhinga amatsha okuphucula nokukhusela impilo yezilwanyana zasefama kufuneka ahlolwe. Ukuqina kwamathumbu kusebenza njengonxibelelwano olubalulekileyo phakathi kwezinto eziluhlaza zokutya ezibizayo kunye nokukhuthaza ukukhula kwiinkukhu. I-asidi ye-butyric ngokukodwa ibonwa njengoncedo olunamandla lwempilo yesisu esele isetyenziswa ekutyeni kwezilwanyana kangangeminyaka engaphezu kwama-20. I-Tributyrind ihambisa i-asidi ye-butyric emathunjini amancinci kwaye isebenza kakhulu ekuchaphazeleni impilo yamathumbu ngokukhawulezisa inkqubo yokulungisa amathumbu, ikhuthaza uphuhliso olufanelekileyo lwe-villi kwaye ilawula iimpendulo zomzimba kwindlela yamathumbu.

Ngoku njengoko amayeza okubulala iintsholongwane esuswa, i-butyric acid sisixhobo esihle sokuxhasa eli shishini ukunciphisa impembelelo embi ye-dysbacteriosis ebonakala ngenxa yolu tshintsho.