Ukukhulisa iinkomo kuthetha ukukhulisa isisu, ukukhulisa iintlanzi kuthetha ukukhulisa amachibi, kwaye ukukhulisa iihagu kuthetha ukukhulisa amathumbu. "Iingcali zezondlo zicinga njalo. Ekubeni impilo yamathumbu iye yaxatyiswa, abantu baqala ukulawula impilo yamathumbu ngeendlela ezithile zesondlo kunye nezobuchwepheshe. Nangona kunjalo, phantse zonke zigxila kwimpilo kunye nesondlo samathumbu amancinci, kwaye amathumbu amakhulu aye atyeshelwa."

Enyanisweni, ukuba umsebenzi wamathumbu amakhulu uqhelekile na, kuchaphazela ngqo ukwenzeka kunye nobungakanani borhudo. Izifo ezininzi zabantu zibangelwa kukonakala kwamathumbu amakhulu, njengesifo samathumbu esibangela izilonda, urhudo olunamafutha, isifo seswekile, isifo sikaKrohn S, i-colitis, umhlaza wamathumbu amakhulu, ukungezwani nokutya, njalo njalo. Ke ngoko, nokuba kukukhulisa iihagu okanye impilo yabantu, kufuneka sinikele ingqalelo eyaneleyo kumathumbu amakhulu.

Umzekelo, ikholoni incinci. Nangona ikholoni ingeyona ndawo iphambili yokugaya nokufunxa, yeyona ndawo inengxaki kakhulu kwindlela yokugaya. Ikholoni yindawo ephambili yokubilisa iintsholongwane, kwaye inani leentsholongwane ezincinci kwikholoni liphindwe kayi-100 000 kunakwi-small intestine; Ixesha lokugcina umxholo wamathumbu kwikholoni liphindwe kayi-5-20 kune-small intestine. Izinto ezinobuthi eziveliswa kukubilisa iintsholongwane zonakalisa ikholoni ixesha elide, zichaphazela ukusebenza kwayo okuqhelekileyo komzimba kwaye zivelise izifo zekholoni. Ukongeza, ngenxa yokuba umsebenzi womqobo wekholoni wonakele, iityhefu kunye neebhaktheriya ziyafuduselwa egazini, nto leyo ebangela i-sepsis kunye nomonakalo wesibindi. Izifundo zifumanise ukuba i-butyric acid eveliswa kukubilisa iintsholongwane zebhaktheriya ibaluleke kakhulu kwimpilo yekholoni, kwaye ukungabikho kwe-butyric acid engapheliyo kudla ngokuba yimbangela yezifo ezininzi zekholoni. Ke ngoko, ukongezwa kwe-butyric acid engaphandle lunyango olubalulekileyo kunyango lwezonyango lwezifo zekholoni (ezifana norhudo, isifo samathumbu esivuthayo, i-ulcerative colitis, umhlaza wekholoni, njl.njl.). Njengesongezo se-butyric acid esibaluleke kakhulu,i-tributyriniye yafundwa kwaye yasetyenziswa ngakumbi nangakumbi.

Xa kuthelekiswa nabantu, imfuyo kunye neenkukhu zinokuba neengxaki zamathumbu amakhulu. Nangona kunjalo, ngenxa yokuba icandelo lesondlo sezilwanyana linika ingqalelo engakumbi ekugayweni nasekufunxeni ukutya kwezilwanyana, sinikela ingqalelo engakumbi kwimpilo yamathumbu amancinci ezilwanyana. Impilo yamathumbu phantse ayijongwanga njengempilo yamathumbu amancinci, kwaye impilo yamathumbu amakhulu ayihoywa. Enyanisweni, iingxaki ezininzi zempilo zemfuyo kunye neenkukhu zinxulumene kakhulu nemathumbu amakhulu, njengorhudo kunye nokuqhina. Ukulawula impilo yamathumbu amakhulu kubaluleke kakhulu ekuphuculeni ukusebenza kwemveliso yezilwanyana.

Umgangatho wesondlo sangoku, nangona unika ingqalelo ekugayweni nasekufunxweni kwamathumbu amancinci, uhlala ungayinaki impembelelo yempilo yamathumbu amakhulu ekusebenzeni kwemveliso yezilwanyana ezikhuliswe. Uninzi lweemveliso ezinxulumene nempilo yamathumbu zihlala zigxila kumathumbu amancinci. Indlela yokulawula amathumbu onke nayo yingxaki ekufuneka iqwalaselwe zizongezo ezisebenzayo.

Iingenelo kunye neempawu ze-triglyceride ekutyeni:

1. Iingenelo ze-triglyceride kwisondlo

(1) Akukho vumba nokufunxwa komswakama;

(2) Ukudlula esiswini: ukugaywa kwe-triglyceride kufuna i-lipase, kwaye akukho lipase esiswini, ngoko ke idlula esiswini ngokwendalo;

(3) Kumathumbu onke: i-butyric acid ayikhutshelwa kuphela emathunjini, kodwa nakwiimveliso ze-butyric acid. I-1kg ingakhupha i-400g ye-butyric acid emathunjini onke.

 

2. Iimpawu eziphambili ze-triglyceride:

(1) Uzinze ngakumbi:i-tributyrinIzinzile ngakumbi kwi-in vitro kuba ayinamaqela e-hydroxyl abonakalayo; I-asidi ye-butyric engaphezulu ngokuphindwe ka-1.5 kune-glycerol i-MONOBUTYRATE ikhutshiwe emzimbeni.

(2) Isebenza ngakumbi: i-pancreatic lipase inomsebenzi ophambili kunye nomsebenzi okhethekileyo wokubola kwe-triglyceride.

(3) Ikhuselekileyo:I-TributyrinInxalenye enye, ngokusisiseko akukho ntsalela ye-butyric acid, akukho ntsalela ye-glycerol kunye ne-catalyst (ngokubanzi yi-asidi enamandla), ngoko ke ayifunxi umswakama kwaye ikhuselekile kwizilwanyana.