Kufuneka ezinye iindlela zonyango lwe-antibiotic ngenxa yokuvalwa kokusetyenziswa kwala mayeza njengezikhuthazi zokukhula kwimveliso yokutya yezilwanyana. Kubonakala ngathi i-Tributyrin idlala indima ekuphuculeni ukusebenza kokukhula kweehagu, nangona iphumelela ngokwamanqanaba ahlukeneyo.

Okwangoku, kuncinci kakhulu okwaziwayo ngemiphumo yayo kulwakhiwo lwe-gut microbiota. Kolu phononongo, siphande utshintsho lwe-gut microbiota kumantshontsho eehagu afumana, xa elumla, i-0.2% tributyrin yongezwa kwisidlo sawo esisisiseko.

Iqela leTributyrin lalinamandla aphuculweyo okuguqula imetabolism yamandla kunye namathuba aphantsi okuguqula imetabolism yecarbohydrate. Ukuqukumbela, iziphumo zethu zibonise ukuba itributyrin inokukhuthaza utshintsho kuluntu lweentsholongwane zamathumbu, olunokuba negalelo ekuphuculeni ukusebenza kwezilwanyana emva kokulunyulwa.

Impembelelo yeTributyrin kutshintsho lweGut Microbiota olunxulumene nokusebenza kweeHagu ezilunyulwayo

Iiparamitha zeMveliso

I-Tributyrin (ekwabizwa ngokuba yi-Glyceryl tributyrate; i-Glycerol tributyrate; i-Glycery tributyrate; i-propane-1,2,3-triyl tributanoate), luhlobo lwe-short chain fatty acid ester.

I-CAS RN: 60-01-5

Inombolo ye-EINECS: 200-451-5

Ifomula: C15H26O6

I-FW: 302.36

Inkangeleko: Imhlophe ukuya kumthubi ulwelo olunamafutha olunevumba elimnandi kancinci.

Ukunyibilika: kunyibilika kwi-ethanol, i-chloroform kunye ne-ether, akunyibiliki kakhulu emanzini (0.010%).

Ubomi beShelf: Iinyanga ezingama-24

Iphakheji: 25KG/ Ibhegi

Indawo yokugcina: Ivalwe kwiindawo ezomileyo nezinomoya

I-Tributyrinyi-triglyceride equlethe iimolekyuli ezintathu ze-butyrate ezifakwe kwi-glycerol, zongeza ubuninzi be-butyrate emva kwe-hydrolyzation yi-pancreatic lipases.

Iimpawu zeTributyrin
Isizukulwana esitsha se-butyrate-glycerol ester ye-butyric acid.
Isisu esidlulayo nge-100%.
Ukuhambisa ii-asidi ze-butyric emathunjini amancinci, akufuneki ukuba zigqunywe.
Ngokwemvelo ifumaneka kubisi nobusi.

Uthelekiso Phakathi kweTributyrin kunye neButyrate Salt

Isiqingatha sobomi se-butyric acid yimizuzu emi-6. I-butyrate kunzima ukuyifikelela kwezinye izicwili kunye namalungu angaphandle kwamathumbu anikwe ngendlela ye-butyric acid okanye i-butyrate. Nangona kunjalo, isiqingatha sobomi se-tributyrin yimizuzu engama-40, kwaye uxinzelelo lwe-plasma lwe-butyrate lunokugcinwa lungaphezulu kwe-0.1mM kangangeeyure eziyi-0.5-4 ngokuyithatha ngomlomo.

Indlela yokusebenza kunye neempawu

Umboneleli wamandla

Njengoko kwaziwa kakhulu, i-butyric acid yi-short-chain fatty acid engumthombo wamandla ophambili weeseli ze-epithelial zamathumbu. Ngaphezulu kwe-70% yamandla okukhula kweeseli ze-epithelial zamathumbu anikezelwa yi-butyric acid. Nangona kunjalo, i-tributyrin inika ixabiso eliphezulu le-butyric acid ekhulula amathumbu xa ithelekiswa nezinye iimveliso ze-butyrate.

Ukukhusela Amathumbu

►I-Tributyrin ikhuthaza ukwanda nokwahluka kweeseli ze-epithelial zamathumbu, ilungisa i-mucosa eyonakeleyo, kwaye yandisa indawo yomphezulu ukuze ifunxe izondlo.

►I-Tributyrin ikhuthaza ukubonakaliswa kweeproteni ze-tight junction emathunjini, igcina ukudibana okuqinileyo phakathi kweeseli, ithintela ii-macromolecules ezifana neebhaktheriya kunye neetyhefu ukuba zingangeni emzimbeni, kwaye igcina umsebenzi wokuthintela umzimba wamathumbu.

►I-Tributyrin ikhuthaza ukukhutshwa kwe-mucin (Muc) kwaye iqinisa umsebenzi wokuthintela iikhemikhali zamathumbu.

Izinga Lokusinda Liphucukile

I-Tributyrin inokukhuthaza ukwenziwa kwe-hemoglobin, iphucule amandla okuthwala ioksijini, iqinise inkqubo yokuxhasa ubomi bendalo, kwaye inokuphucula ukusebenza kwe-mitochondria kwaye ikhuthaze ukwenziwa kwe-ATP, into yamandla eqhuba umsebenzi wobomi, ukuze iphucule izinga lokusinda okanye izilwanyana.

I-Anti-Inflammatory kunye ne-Antibacteria

►Ngokuthintela umsebenzi we-NF-Kb, TNF-α kunye ne-TLR, i-Tributyrin inokunciphisa umonakalo wokudumba.

►I-Tributyrin ikhuthaza ukubonakaliswa kweepeptide zokuzikhusela zendalo, ezinokumelana ne-pathogen kunye ne-virus ngokubanzi.