Kufuneka ezinye iindlela zonyango lwe-antibiotic ngenxa yokuvalwa kokusetyenziswa kwala mayeza njengezikhuthazi zokukhula kwimveliso yokutya yezilwanyana. Kubonakala ngathi i-Tributyrin idlala indima ekuphuculeni ukusebenza kokukhula kweehagu, nangona iphumelela ngokwamanqanaba ahlukeneyo.

Okwangoku, kuncinci kakhulu okwaziwayo ngemiphumo yayo kulwakhiwo lwe-gut microbiota. Kolu phononongo, siphande utshintsho lwe-gut microbiota kumantshontsho eehagu afumana, xa elumla, i-0.2% tributyrin yongezwa kwisidlo sawo esisisiseko.

Iqela leTributyrin lalinamandla aphuculweyo okuguqula imetabolism yamandla kunye namathuba aphantsi okuguqula imetabolism yecarbohydrate. Ukuqukumbela, iziphumo zethu zibonise ukuba i-tributyrin inokukhuthaza utshintsho kuluntu lweentsholongwane zamathumbu, olunokuba negalelo ekuphuculeni ukusebenza kwezilwanyana emva kokulunyulwa.

Impembelelo yeTributyrin kutshintsho lweGut Microbiota olunxulumene nokusebenza kweeHagu ezilunyulwayo

Iiparamitha zeMveliso

I-Tributyrin (ekwabizwa ngokuba yi-Glyceryl tributyrate; i-Glycerol tributyrate; i-Glycery tributyrate; i-propane-1,2,3-triyl tributanoate), luhlobo lwe-short chain fatty acid ester.

I-CAS RN: 60-01-5

Inombolo ye-EINECS: 200-451-5

Ifomula: C15H26O6

I-FW: 302.36

Inkangeleko: Ilulwelo olunamafutha olumhlophe ukuya kolutyheli olunevumba elimnandi kancinci.

Ukunyibilika: kunyibilika kwi-ethanol, i-chloroform kunye ne-ether, akunyibiliki kakhulu emanzini (0.010%).

Ubomi beShelf: Iinyanga ezingama-24

Iphakheji: 25KG/ Ibhegi

Indawo yokugcina: Ivalwe kwiindawo ezomileyo nezinomoya

I-Tributyrinyi-triglyceride equlethe iimolekyuli ezintathu ze-butyrate ezifakwe kwi-glycerol, zongeza ubuninzi be-butyrate emva kwe-hydrolyzation yi-pancreatic lipases.

Iimpawu zeTributyrin
Isizukulwana esitsha se-butyrate-glycerol ester ye-butyric acid.
Isisu esidlulayo nge-100%.
Ukuhambisa ii-asidi ze-butyric emathunjini amancinci, akufuneki ukuba zigqunywe.
Ngokwemvelo ifumaneka kubisi nobusi.

Uthelekiso Phakathi kweTributyrin kunye neButyrate Salt

Isiqingatha sobomi se-butyric acid yimizuzu emi-6. I-butyrate kunzima ukuyifikelela kwezinye izicwili kunye namalungu angaphandle kwamathumbu anikwe ngendlela ye-butyric acid okanye i-butyrate. Nangona kunjalo, isiqingatha sobomi se-tributyrin yimizuzu engama-40, kwaye uxinzelelo lwe-plasma lwe-butyrate lunokugcinwa lungaphezulu kwe-0.1mM kangangeeyure eziyi-0.5-4 ngokuyithatha ngomlomo.

Indlela yokusebenza kunye neempawu

Umboneleli wamandla

Njengoko kwaziwa kakhulu, i-butyric acid yi-short-chain fatty acid engumthombo wamandla ophambili weeseli ze-epithelial zamathumbu. Ngaphezulu kwe-70% yamandla okukhula kweeseli ze-epithelial zamathumbu anikezelwa yi-butyric acid. Nangona kunjalo, i-tributyrin inika ixabiso eliphezulu le-butyric acid ekhulula amathumbu xa ithelekiswa nezinye iimveliso ze-butyrate.

Ukukhusela Amathumbu

►I-Tributyrin ikhuthaza ukwanda nokwahluka kweeseli ze-epithelial zamathumbu, ilungisa i-mucosa eyonakeleyo, kwaye yandisa indawo yomphezulu ukuze ifunxe izondlo.

►I-Tributyrin ikhuthaza ukubonakaliswa kweeproteni ze-tight junction emathunjini, igcina ukudibana okuqinileyo phakathi kweeseli, ithintela ii-macromolecules ezifana neebhaktheriya kunye neetyhefu ukuba zingangeni emzimbeni, kwaye igcina umsebenzi wokuthintela umzimba wamathumbu.

►I-Tributyrin ikhuthaza ukukhutshwa kwe-mucin (Muc) kwaye iqinisa umsebenzi wokuthintela iikhemikhali zamathumbu.

Izinga Lokusinda Liphucukile

I-Tributyrin inokukhuthaza ukwenziwa kwe-hemoglobin, iphucule amandla okuthwala ioksijini, iqinise inkqubo yokuxhasa ubomi bendalo, kwaye inokuphucula ukusebenza kwe-mitochondria kwaye ikhuthaze ukwenziwa kwe-ATP, into yamandla eqhuba umsebenzi wobomi, ukuze iphucule izinga lokusinda okanye izilwanyana.

I-Anti-Inflammatory kunye ne-Antibacteria

►Ngokuthintela umsebenzi we-NF-Kb, TNF-α kunye ne-TLR, i-Tributyrin inokunciphisa umonakalo wokudumba.

►I-Tributyrin ikhuthaza ukubonakaliswa kweepeptide zokuzikhusela zendalo, ezinokumelana ne-pathogen kunye ne-virus ngokubanzi.