I-Potassium Formate, isongezo sokuqala sesondlo esingenazibulali ntsholongwane esavunywa yiManyano yaseYurophu ngo-2001 saza savunywa liSebe lezoLimo laseTshayina ngo-2005, siqokelele isicwangciso sesicelo esisele sikhulile ngokwentelekiso ngaphezulu kweminyaka eli-10, kwaye amaphepha ophando amaninzi ngaphakathi nangaphandle anike ingxelo ngeziphumo zawo kumanqanaba ohlukeneyo okukhula kweehagu.

I-Necrotizing enteritis sisifo seenkukhu zehlabathi jikelele esibangelwa yintsholongwane yegram-positive (i-Clostridium perfringens), eya kwandisa ukufa kweenkukhu zenyama kwaye yehlise ukukhula kweenkukhu ngendlela encinci. Zombini ezi ziphumo zonakalisa intlalontle yezilwanyana kwaye zizisa ilahleko enkulu yezoqoqosho kwimveliso yeenkukhu. Kwimveliso yokwenyani, i-antibiotics idla ngokudityaniswa ukondla ukuthintela ukwenzeka kwe-necrotizing enteritis. Nangona kunjalo, umnxeba wokuthintelwa kwamayeza okubulala iintsholongwane kwisondlo uyakhula, kwaye ezinye izisombululo ziyafuneka ukuze kuthathelwe indawo isiphumo sothintelo lwe-antibiotics. Uphononongo lufumene ukuba ukongeza i-asidi ye-organic okanye iityuwa zabo ekudleni kunokuthintela umxholo we-Clostridium perfringens, ngaloo ndlela ukunciphisa ukwenzeka kwe-necrotizing enteritis. I-Potassium formate ichithwa kwi-fomic acid kunye nefomati ye-potassium emathunjini. Ngenxa yepropathi ye-covalent bond kwiqondo lokushisa, enye i-asidi ye-formic ingena ngokupheleleyo emathunjini. Olu vavanyo lusebenzise inkukhu eyosulelwe yi-necrotizing enteritis njengomzekelo wophando ukuphanda iziphumo zeifomati ye potassiumekusebenzeni kwayo kokukhula, i-microbiota yamathumbu, kunye nomxholo omfutshane we-fatty acid.

1. Isiphumo sePotassium DiformatekwiNtsebenzo yokuKhula kweeNkuku zeNkuku ezosulelwe yiNecrotizing Enteritis.

Iziphumo zovavanyo zibonise ukuba i-potassium fomati yayingenayo impembelelo ebalulekileyo ekusebenzeni kokukhula kwee-broilers kunye okanye ngaphandle kwe-necrotizing enteritis infection, ehambelana neziphumo zophando zikaHernandez et al. (2006). Kwafunyaniswa ukuba i-dose efanayo ye-calcium formate yayingenayo impembelelo ebalulekileyo ekuzuzeni ubunzima bemihla ngemihla kunye nomlinganiselo wokutya we-broilers, kodwa xa ukongezwa kwe-calcium fomati ifikelele kwi-15 g / kg, yanciphisa kakhulu ukusebenza kokukhula kwee-broilers (uPatten kunye ne-Waldroup, i-1988). Nangona kunjalo, uSelle et al. (2004) yafumanisa ukuba ukongeza i-6 g / kg yefomati ye-potassium ekudleni kwandisa kakhulu ubunzima kunye nokutya kokutya kweenkukhu ze-broiler ngeentsuku eziyi-16-35. Kukho ngoku kukho iingxelo ezimbalwa zophando ngendima ye-organic acids ekuthinteleni usulelo lwe-necrotizing enteritis. Olu vavanyo lufumanise ukuba ukongeza i-4 g/kg yefomati ye-potassium ekutyeni kunciphise kakhulu izinga lokufa kwee-broilers, kodwa kwakungekho budlelwane be-dose-effect phakathi kokunciphisa izinga lokufa kunye nomthamo wefomati ye-potassium eyongeziweyo.

2. Isiphumo sePotassium DiformateKwiMicrobial Content kwiTissues kunye namaOrgans of Broilers osulelwe yiNecrotizing Enteritis

Ukongezwa kwe-45mg / kg i-bacitracin zinc kwisondlo kunciphisa ukufa kwee-broilers ezisuleleke nge-necrotizing enteritis, kwaye kwangaxeshanye kunciphisa umxholo weClostridium perfringens kwijejunum, eyayihambelana neziphumo zophando zikaKocher et al. (2004). Kwakungekho mpembelelo ibalulekileyo yokutya kwe-potassium diformate supplementation kumxholo we-Clostridium perfringens kwi-jejunum ye-broilers ezosulelwe yi-necrotizing enteritis kwiintsuku ze-15. Walsh et al. (2004) yafumanisa ukuba ukutya okune-asidi ephezulu kunefuthe elibi kwi-asidi ephilayo, ngoko ke, i-acidity ephezulu ye-protein yokutya inokunciphisa umphumo wokukhusela we-potassium fomati kwi-necrotizing enteritis. Olu vavanyo luye lwafumanisa ukuba i-potassium formate yandisa umxholo we-lactobacilli kwisisu se-muscle ye-35d yenkukhu ye-broiler, engahambelani ne-Knarreborg et al. (2002) ukufumanisa kwi-vitro ukuba i-potassium fomati yanciphisa ukukhula kwe-lactobacilli kwisisu sehagu.

3.Impembelelo ye-potassium 3-dimethylformate kwi-pH yenyama kunye nomxholo omfutshane we-fatty acid kwiinkukhu ze-broiler ezosulelwe yi-necrotizing enteritis.

Impembelelo ye-antibacterial ye-organic acids ikholelwa ukuba iyenzeka kakhulu kwindawo ephezulu yendlela yokugaya. Iziphumo zolu vavanyo zibonise ukuba i-potassium dicarboxylate yonyusa umxholo we-asidi ye-formic kwi-duodenum kwiintsuku ze-15 kunye ne-jejunum kwiintsuku ze-35. UMroz (2005) wafumanisa ukuba kukho izinto ezininzi ezichaphazela isenzo se-organic acids, njenge-feed pH, i-buffering / acidity, kunye ne-dietary electrolyte balance. I-acidity ephantsi kunye nemilinganiselo ephezulu ye-electrolyte yokutya inokukhuthaza ukuchithwa kwefomati ye-potassium kwi-formic acid kunye ne-potassium fomati. Ke ngoko, inqanaba elifanelekileyo le-asidi kunye nemilinganiselo ye-electrolyte elinganayo ekutyeni kunokuphucula ukuphuculwa kokukhula kokukhula kweebroilers ngefomati ye-potassium kunye nefuthe layo lokuthintela kwi-necrotizing enteritis.

Ukuqukumbela

Iziphumo zeifomati ye potassiumkwimodeli ye-necrotizing enteritis kwiinkukhu ze-broiler yabonisa ukuba i-potassium formate inokunciphisa ukuhla kokukhula kokukhula kweenkukhu ze-broiler phantsi kweemeko ezithile ngokwandisa ubunzima bomzimba kunye nokunciphisa ukufa, kwaye inokusetyenziswa njengesongezo sokutya ukulawula ukusuleleka kwe-necrotizing enteritis kwiinkukhu ze-broiler.