I-potassium formate, isongezo sokuqala sokutya esingesiso isibulali-ntsholongwane esamkelwe yiManyano yaseYurophu ngo-2001 saza savunywa yiSebe lezoLimo laseTshayina ngo-2005, siqokelele isicwangciso sesicelo esivuthiweyo kangangeminyaka engaphezu kwe-10, kwaye amaphepha amaninzi ophando ngaphakathi nangaphandle axele ngemiphumo yaso kumanqanaba ahlukeneyo okukhula kweengulube.

I-Necrotizing enteritis sisifo seenkuku esibangelwa yintsholongwane yegram-positive (Clostridium perfringens), esiya kunyusa ukufa kweenkukhu zenkukhu kwaye sinciphise ukukhula kweenkukhu ngendlela engaphantsi kweklinikhi. Zombini ezi ziphumo zonakalisa impilo-ntle yezilwanyana kwaye zizisa ilahleko enkulu kwezoqoqosho kwimveliso yeenkukhu. Kwimveliso yokwenyani, ii-antibiotics zihlala zongezwa ekutyeni ukuthintela ukwenzeka kwe-necrotizing enteritis. Nangona kunjalo, ubizo lokuthintela ii-antibiotics ekutyeni luyanda, kwaye ezinye izisombululo ziyafuneka ukuze kuthathelwe indawo isiphumo sokuthintela ii-antibiotics. Olu phononongo lufumanise ukuba ukongeza ii-organic acids okanye iityuwa zazo ekutyeni kunokuthintela umxholo weClostridium perfringens, ngaloo ndlela kunciphisa ukwenzeka kwe-necrotizing enteritis. I-Potassium formate iyabola ibe yi-formic acid kunye ne-potassium formate emathunjini. Ngenxa yepropathi ye-covalent bond kubushushu, i-formic acid ethile ingena ngokupheleleyo emathunjini. Olu vavanyo lusebenzise inkukhu eyosulelwe yi-necrotizing enteritis njengomzekelo wophando ukuphanda iziphumo zei-potassium formatemalunga nokusebenza kwayo ekukhuleni, i-intestinal microbiota, kunye nomxholo we-short chain fatty acid.

1. Isiphumo seI-Potassium Diformatemalunga nokukhula kweeNkukhu zeNkuku ezinesifo se-Necrotizing Enteritis.

Iziphumo zovavanyo zibonise ukuba i-potassium formate ayinampembelelo ibalulekileyo ekusebenzeni kokukhula kweenkukhu ezinazo okanye ezingenazo izifo ezibangelwa yi-necrotizing enteritis, nto leyo ehambelana neziphumo zophando lukaHernandez et al. (2006). Kufunyaniswe ukuba idosi efanayo ye-calcium formate ayinampembelelo ibalulekileyo ekunyukeni kobunzima bemihla ngemihla kunye nomlinganiselo wokutya kweenkukhu ezinazo, kodwa xa ukongezwa kwe-calcium formate kufikelele kwi-15 g/kg, kunciphisa kakhulu ukusebenza kokukhula kweenkukhu ezinazo (Patten kunye noWaldroup, 1988). Nangona kunjalo, uSelle et al. (2004) bafumanise ukuba ukongeza i-6 g/kg ye-potassium formate ekutyeni kwandisa kakhulu ukwanda kobunzima kunye nokutya kweenkukhu ezinazo ngeentsuku ezili-16-35. Okwangoku zimbalwa iingxelo zophando malunga nendima ye-organic acids ekuthinteleni usulelo lwe-necrotizing enteritis. Olu vavanyo lufumanise ukuba ukongeza i-4 g/kg ye-potassium formate ekutyeni kunciphisa kakhulu izinga lokufa kweenkukhu ezinazo, kodwa bekungekho budlelwane phakathi kokunciphisa izinga lokufa kunye nobungakanani be-potassium formate eyongeziweyo.

2. Isiphumo seI-Potassium Diformatemalunga nomxholo weentsholongwane kwiithishu nakwizitho zeenkukhu ezinesifo se-Necrotizing Enteritis

Ukongezwa kwe-45mg/kg ye-bacitracin zinc ekutyeni kunciphisa ukufa kweenkuku ezinesifo se-necrotizing enteritis, kwaza kwangaxeshanye kunciphisa umxholo weClostridium perfringens kwi-jejunum, nto leyo eyayihambelana neziphumo zophando zikaKocher et al. (2004). Akukho mpembelelo ibalulekileyo yokongezwa kwe-potassium diformate kumxholo weClostridium perfringens kwi-jejunum yeenkukhu ezinesifo se-necrotizing enteritis kangangeentsuku ezili-15. UWalsh et al. (2004) bafumanise ukuba ukutya okune-acidity ephezulu kunempembelelo embi kwi-organic acids, ngoko ke, i-acidity ephezulu yokutya okuneproteni ephezulu kunokunciphisa umphumo wokuthintela we-potassium formate kwi-necrotizing enteritis. Olu vavanyo lukwafumanise ukuba i-potassium formate yonyusa umxholo we-lactobacilli esiswini semisipha yeenkukhu ze-35d broiler, into engahambelaniyo noKnarreborg et al. (2002) abafumanise kwi-vitro ukuba i-potassium formate inciphisa ukukhula kwe-lactobacilli esiswini sehagu.

3.Impembelelo ye-potassium 3-dimethylformate kwi-pH yezicubu kunye nomxholo we-short chain fatty acid kwiinkuku ze-broiler ezinesifo se-necrotizing enteritis

Isiphumo sokulwa neentsholongwane se-organic acids kukholelwa ukuba senzeka ikakhulu kwinxalenye ephezulu yendlela yokugaya ukutya. Iziphumo zolu vavanyo zibonise ukuba i-potassium dicarboxylate yonyusa umxholo we-formic acid kwi-duodenum kwiintsuku ezili-15 kunye ne-jejunum kwiintsuku ezingama-35. UMroz (2005) ufumanise ukuba kukho izinto ezininzi ezichaphazela ukusebenza kwe-organic acids, ezifana ne-feed pH, i-buffering/acidity, kunye ne-dietary electrolyte balance. I-acidity ephantsi kunye ne-electrolyte balance values ​​ephezulu ekutyeni kunokukhuthaza ukwahlukana kwe-potassium formate kwi-formic acid kunye ne-potassium formate. Ke ngoko, inqanaba elifanelekileyo le-acidity kunye ne-electrolyte balance values ​​ekutyeni kunokuphucula ukusebenza kokukhula kwe-broilers yi-potassium formate kunye nesiphumo sayo sokuthintela kwi-necrotizing enteritis.

Isiphelo

Iziphumo zei-potassium formateKwimodeli ye-necrotizing enteritis kwiinkukhu ze-broiler, kuboniswe ukuba i-potassium formate inokunciphisa ukwehla kokusebenza kokukhula kweenkukhu ze-broiler phantsi kweemeko ezithile ngokunyusa ubunzima bomzimba nokunciphisa ukufa, kwaye ingasetyenziswa njengesongezelelo sokondla ukulawula usulelo lwe-necrotizing enteritis kwiinkukhu ze-broiler.