I-asidi ye-guanylacetic, ekwaziwa ngokuba yi-guanylacetic acid, yi-amino acid analogue eyenziwe nge-glycine kunye ne-L-lysine.

I-Guanylacetic acid inokwenza i-creatine phantsi kwe-catalysis yee-enzymes kwaye yeyona nto ifunekayo ukuze kwenziwe i-creatine. I-Creatine ibonwa njenge-energy buffer, kwaye umsebenzi wayo ophambili kukwenza i-creatine ene-phosphorylated phantsi kwesenzo se-creatine kinase.

Thatha inxaxheba kuhambo lwe-adenosineumjikelo we-hosphate (ATP). Xa amandla e-ATP enganelanga, i-phosphocreatine idlulisela ngokukhawuleza iqela le-phosphate kwi-adenosine diphosphate nge-creatine kinase ize iyiguqulele kwi-adenosine triphosphate.

 

Ukusetyenziswa kwizilwanyana ezitya inyama:

Ukongeza i-0.12%, 0.08%, kunye ne-0.04% ye-guanylacetic acid ekutyeni kweegusha ezili-120 ezifuywe ziibharn Tan ezinobunzima obumalunga neekhilogram ezingama-20, ngokulandelelana, kubonise ukuba ukongezwa kwe-0.12% kunye ne-0.08% ye-guanylacetic acid kwandisa kakhulu ukutyeba kwemihla ngemihla, amafutha e-intramuscular, kunye nomxholo weproteni, kwaye kunciphisa kakhulu umxholo wamafutha e-carcass.

 

Ukongezwa kwe-0.08%i-guanylacetic acidipesenti yenyama ecocekileyo yonyuswe nge-9.77%. Ngokusebenzisa indlela yokuvelisa igesi kwi-vitro, isiphumo sokongeza amanqanaba ahlukeneyo e-guanylacetic acid kwisisu seenkomo ezityheli sifundwe. Kufunyaniswe ukuba ukongezwa kwe-guanylacetic acid eyi-0.4% kwandisa kakhulu imveliso yegesi, kwaye ukuxinana kwe-ammonia nitrogen kuqala kwanda kwaze kwancipha.

Ngoko ke, kunokuqikelelwa ukuba ukongeza i-guanylacetic acid ekutyeni kwemihla ngemihla kunokuphucula imeko yangaphakathi ye-rumen kunye nendlela yokubilisa iinkomo ezityheli.

Ukusetyenziswa kwinkukhu:

Ukongeza i-800 mg/kg, i-1600 mg/kg, i-4000 mg/kg, kunye ne-8000 mg/kg ye-guanylacetic acid ekutyeni kwemihla ngemihla kweenkukhu kubonise ukuba ukongeza i-800-4000 mg/kg ye-guanylacetic acid ekutyeni kwandisa kakhulu ukutyeba kwemihla ngemihla kweenkukhu, kunciphisa umlinganiselo wokutya nobunzima beenkukhu kwiintsuku ezingama-22-42 ubudala. Ukongeza i-8000 mg/kg ye-guanylacetic acid iphucule izalathisi ze-biochemical ze-serum ezifana ne-urea nitrogen, izalathisi zegazi, kunye ne-bilirubin iyonke Akukho mpembelelo ibalulekileyo kwizalathisi eziphambili zezitho zomzimba, nto leyo ebonisa ukuba ukongeza i-8000 mg/kg ye-guanylacetic acid ekutyeni kwemihla ngemihla kweenkukhu kuyanyamezeleka.

Ukongeza i-200 mg/kg, i-400 mg/kg, i-600 mg/kg, kunye ne-800 mg/kg ye-guanylacetic acid kwisondlo seenkuku kubonise ukwanda okukhulu kobunzima obuqhelekileyo bemihla ngemihla xa kuthelekiswa neqela lolawulo. Iziphumo ezilungileyo zifunyenwe xa amanqanaba okongeza ayeyi-600 kunye ne-800 mg/kg.

Ukuze kufundwe impembelelo ye-guanylacetic acid kumgangatho wesidoda kwiinkuku, kukhethwe iinkukhu ezingama-20 ezineeveki ezingama-28 ubudala ukuze zondle ukutya okuqulethe i-0%, 0.06%, 0.12%, kunye ne-0.18% ye-guanylacetic acid. Iziphumo zophando zifumanise ukuba ukongeza i-0.12% ye-guanylacetic acid ekutyeni kwandisa kakhulu inani lesidoda, uxinaniso lwesidoda, kunye nomsebenzi wesidoda kwiinkuku, nto leyo ebonisa ukuba ukongeza i-guanylacetic acid ekutyeni kunokuphucula umgangatho wesidoda ngempumelelo. Yongeza i-0.0314%, 0.0628%, 0.0942%, kunye ne-0.1256% ye-guanylacetic acid ekutyeni kwemihla ngemihla kweenkukhu, kwaye ubeke amaqela amabini olawulo (iqela lolawulo 1 kukutya okusekwe kwizityalo ngaphandle kwento eyongeziweyo, kwaye iqela lolawulo 2 kukutya okunokutya kwentlanzi okongeziweyo). Amaqela amathandathu angentla okutya kwemihla ngemihla anomgangatho ofanayo wamandla kunye neeminerali.

Iziphumo zovavanyo zibonisa ukuba amazinga okwanda kobunzima bamaqela amane ane-guanylacetic acid eyongeziweyo kunye neqela lolawulo lesi-2 aphezulu kunalawo eqela lolawulo loku-1, Iqela lolawulo lesi-2 libe nefuthe elihle kakhulu lokwanda kobunzima, lilandelwa liqela le-guanylacetic acid eliyi-0.0942%; Iqela lolawulo lesi-2 libe nelona qondo lilungileyo lezinto ezisetyenziswayo xa kuthelekiswa nobunzima, lilandelwa liqela le-guanylacetic acid eliyi-0.1256%.

Ukusetyenziswa kwinkukhu:

Ukongeza i-800 mg/kg, i-1600 mg/kg, i-4000 mg/kg, kunye ne-8000 mg/kg yei-guanylacetic acidkwisondlo semihla ngemihla seenkuku zenyama kubonise ukuba ukongeza i-800-4000 mg/kg ye-guanylacetic acid kwisondlo kwandisa kakhulu ukutyeba kwemihla ngemihla kweenkukhu zenyama, kunciphisa umlinganiselo wokutya ukuya kubunzima beenkukhu kwiintsuku ezingama-22-42 ubudala. Ukongeza i-8000 mg/kg ye-guanylacetic acid ephucukileyo kwi-serum biochemical indicators ezifana ne-urea nitrogen, izalathisi zegazi, kunye ne-bilirubin iyonke Akukho mpembelelo ibalulekileyo kwizalathisi eziphambili zomzimba, nto leyo ebonisa ukuba ukongeza i-8000 mg/kg ye-guanylacetic acid kwisondlo semihla ngemihla seenkuku zenyama kuyanyamezeleka. Ukongeza i-200 mg/kg, 400 mg/kg, 600 mg/kg, kunye ne-800 mg/kg ye-guanylacetic acid kwisondlo seenkuku zenyama kubonise ukwanda okukhulu kwi-avareji yokunyuka kobunzima bemihla ngemihla xa kuthelekiswa neqela lolawulo. Iziphumo ezilungileyo zifunyenwe xa amanqanaba okongezwa ayeyi-600 kunye ne-800 mg/kg.

Ukuze kufundwe impembelelo ye-guanylacetic acid kumgangatho wesidoda kwiinkuku, kukhethwe iinkukhu ezingama-20 ezineeveki ezingama-28 ubudala ukuze zondle ukutya okuqulethe i-0%, 0.06%, 0.12%, kunye ne-0.18% ye-guanylacetic acid. Iziphumo zophando zifumanise ukuba ukongeza i-0.12% ye-guanylacetic acid ekutyeni kwandisa kakhulu inani lesidoda, uxinaniso lwesidoda, kunye nomsebenzi wesidoda kwiinkuku, nto leyo ebonisa ukuba ukongeza i-guanylacetic acid ekutyeni kunokuphucula umgangatho wesidoda ngempumelelo. Yongeza i-0.0314%, 0.0628%, 0.0942%, kunye ne-0.1256% ye-guanylacetic acid ekutyeni kwemihla ngemihla kweenkukhu, kwaye ubeke amaqela amabini olawulo (iqela lolawulo 1 kukutya okusekwe kwizityalo ngaphandle kwento eyongeziweyo, kwaye iqela lolawulo 2 kukutya okunokutya kwentlanzi okongeziweyo). Amaqela amathandathu angentla okutya kwemihla ngemihla anomgangatho ofanayo wamandla kunye neeminerali. Iziphumo zovavanyo zibonisa ukuba amazinga okwanda kobunzima bamaqela amane ane-guanylacetic acid eyongeziweyo kunye neqela lolawulo lesi-2 aphezulu kunalawo eqela lolawulo loku-1, Iqela lolawulo lesi-2 libe nefuthe elihle kakhulu lokwanda kobunzima, lilandelwa yi-0.0942%i-guanylacetic acidIqela lolawulo 2 lalinomlinganiselo ongcono kakhulu wezinto ezisetyenzisiweyo xa kuthelekiswa nobunzima, lilandelwa liqela le-guanylacetic acid eliyi-0.1256%.