Iimveliso ezahlukeneyo zee-antibiotic kwimveliso yeenkukhu ziyavalwa kancinci kancinci kwihlabathi liphela ngenxa yeengxaki ezimbi eziquka iintsalela zee-antibiotic kunye nokuxhathisa ii-antibiotic. I-Tributyrin yayiyeyona ndlela inokwenzeka endaweni yee-antibiotics. Iziphumo zolu phononongo zibonise ukuba i-tributyrin inokuphucula ukusebenza kokukhula ngokuguqula izalathisi ze-biochemical yegazi kunye nokwakheka kwe-cecal microflora yee-broilers ezityheli. Ngokolwazi lwethu, zimbalwa izifundo eziphande imiphumo ye-tributyrin kwi-intestinal microbiota kunye nolwalamano lwayo nokusebenza kokukhula kwii-broilers. Oku kuya kubonelela ngesiseko sesayensi sokusetyenziswa kwe-tributyrin ekukhuliseni izilwanyana kweli xesha emva kwee-antibiotic.

I-asidi ye-butyric iveliswa ngaphakathi kwe-lumen yamathumbu esilwanyana ngokubiliswa kweebhaktheriya ngee-carbohydrates zokutya ezingagayiwayo kunye neeproteni zendalo. I-90% yale asidi ye-butyric inyibilikiswa ziiseli ze-cecal epithelial okanye ii-colonocytes ukuze ibonelele ngemiphumo emininzi eluncedo kwimpilo yamathumbu.

Nangona kunjalo, i-free butyric acid inevumba elibi kwaye kunzima ukuyiphatha xa isetyenziswa. Ukongeza, i-free butyric acids ibonakalisiwe ukuba ifunxwa kakhulu kwindlela ephezulu yesisu, nto leyo ebangela ukuba uninzi lungafikeleli kumathumbu amakhulu, apho i-butyric acid iya kusebenza khona kakhulu.

Ke ngoko, i-butyrate yetyuwa yesodiyam ethengiswayo iye yaphuhliswa ukuze kube lula ukuyiphatha nokuthintela ukukhutshwa kwe-butyric acid kwindlela ephezulu yesisu.

Kodwa i-tributyrin ine-butyric acid kunye ne-mono-butyrin kwaye kwindlela ephezulu yesisu, i-tributyrin ihanjiswa ibe yi-butyric acid kunye ne-α-mono-butyrin kodwa kwi-hindgut, imolekyuli ephambili iya kuba yi-α-monobutyrin enika amandla angakumbi, ukukhulisa ukukhula kwemisipha kunye nokukhuthaza uphuhliso lwe-capillary ukuze kuthuthwe izondlo ezingcono.

Kukho iingxaki ezininzi ezinxulumene nempilo yamathumbu eenkukhu eziquka:

• isisu esirhudayo
• isifo sokungafunxwa kwesisu
• i-coccidiosis
• i-necrotic enteritis

Ukongezwa kwe-tributyrin kuye kwasetyenziswa kakhulu ukulwa neengxaki zamathumbu, kwaye ekugqibeleni kuphucula impilo yamathumbu enkukhu.

Kwiinkukhu ezifuywayo ezikwi-layer, iyakwazi ukuphucula ukufunxwa kwe-calcium ngakumbi kwiinkukhu ezindala ezizalela amaqanda kwaye iphucule umgangatho wamaqokobhe amaqanda.

Kwiintsana zeehagu, utshintsho lokulunyulwa lixesha elibalulekileyo ngenxa yoxinzelelo olukhulu olubangelwa kukutshintsha ukusuka kulwelo ukuya kukutya okuqinileyo, ukutshintsha kwendawo ezikuyo, kunye nokuxubana neemazi ezintsha.

Kwilingo lakutshanje elenziwe ngamantshontsho ehagu eRivalea, kuboniswe ngokucacileyo ukuba ukongeza ukutya kweTributyrin /MT okuziikhilogram ezingama-2.5 emva kokuyekiswa kweentsana kangangeentsuku ezingama-35 kuphucule ukutyeba komzimba nge-5% kunye nomlinganiselo wokuguqulwa kokutya ngamanqaku ama-3.

I-Tributyrin ingasetyenziswa nasebisini njengento ethatha indawo yobisi olupheleleyo kwaye ithintela kancinci impembelelo embi enayo izinto ezithatha indawo yobisi ekuphuhlisweni kwesisu.