1.IiPropati zePhysicochemical
Benzoic acid(benzenecarboxylic acid) yeyona asidi enuka kamnandi eneasidi ebuthathaka (i-dissociation constant 4.20). Inyibilika kancinane emanzini kodwa inyibilika ngokulula kwizinyibilikisi zendalo ezifana ne-ethanol. Ngenxa ye-lipophilicity eyomeleleyo, inokungena kwi-microbial cell membranes kwaye isebenzise imiphumo yokulwa ne-antibacterial ngokuthintela ukufunyanwa kwe-amino acid, ukuphazamisa umsebenzi we-enzyme yokuphefumula, kunye nokuthintela ukuphendulwa kwe-acetyl-CoA condensation.

2.Antimicrobial Spectrum: Isebenza ngokuchasene neebhaktheriya, ukungunda, kunye negwele, kunye neziphumo eziphuculweyo zolondolozo kwindawo ezineasidi (umzekelo, xa ziguqulelwa kwiityuwa zebenzoate).

3.I-Metabolism kunye noKhuseleko

Kwizilwanyana, i-benzoic acid igaywa ngokuyintloko esibindini, ngaphezulu kwe-85% ephuma kumchamo njenge-hippuric acid, ishiya phantse kungabikho ntsalela kwaye ibangela kungabikho ukuphazamiseka kwibhalansi ye-acid-base.
Abantu kunye neehagu zibonakalisa iindlela ezifanayo zemetabolism, kunye nokukhupha inkunkuma egqibeleleyo kwiiyure ezingama-24, ebonisa ukhuseleko oluphezulu.

II. Usetyenziso oluKhethekileyo kuSondlo

Imimiselo kunye neMigangatho yeDosage

EU: Ukususela ngo-2003, i-benzoic acid iye yavunyelwa njenge-acidifier kwisondlo sehagu kwi-0.5% ~ 1.0%.
eTshayina: Idweliswe njengomlawuli we-pH kunye nesilondolozi kwiIkhathalogu eyongezelelweyo yokutya (2013), ngaphandle kwemida yedosi ecacileyo kodwa ireferensi yemigangatho yokutya ye-0.2 ~ 1.0 g/kg.

Imisebenzi kunye nokuSebenza

Enye indlela yeAntibiotic: Ukulandela ukuvalwa kwe-EU's 2006 kumayeza okubulala iintsholongwane, i-benzoic acid yaba yeyona ndawo iphambili ngenxa yeempawu zayo zokulwa neentsholongwane ezibanzi, ngakumbi ekuthinteleni urhudo lwasemva kokulunyulwa (PWD) kunye nokuphucula ukukhula kwamantshontsho ehagu.
Ukukhula kweNtsebenzo: Uphononongo lubonisa ukuba ukongeza i-0.5% ye-benzoic acid kuphucula ukutya kunye nokunyuka komzimba kumantshontsho alunyulwayo.

Ukuthelekisa kunye nezinye izongezo

Xa kuthelekiswa ne-potassium diformate, i-benzoic acid ifunxwa ngokukhawuleza kwi-foregut kwaye ifuna itekhnoloji yokwambathisa ukuze isebenze kwi-hindgut, ngelixa i-potassium diformate ijolise ngqo kwi-duodenum, inikezela ngokusebenza okuphezulu kwe-antimicrobial.