Igama:γ- i-aminobutyric acid(IsiNgesi)GI-ABA）

Inombolo ye-CAS: 56-12-2

Izithethantonye: 4-Ai-minobutyric acid; i-ammonia butyric acid;I-asidi yepipecolic.

1. Impembelelo ye-GABA ekutyeni kwezilwanyana kufuneka ihlale ihleli ngexesha elithile. Ukutya okutyiwayo kunxulumene kakhulu nokusebenza kwemveliso yemfuyo kunye neenkukhu. Njengomsebenzi onzima wokuziphatha, ukutya kulawulwa kakhulu yinkqubo yemithambo-luvo ephakathi. Iziko lokuhlutha (i-ventromedial nucleus ye-hypothalamus) kunye neziko lokutya (indawo ye-lateral hypothalamus) ngabalawuli bezilwanyana.

Iziko elisisiseko lokutya iGABA linokubangela ukondliwa kwezilwanyana ngokuthintela umsebenzi weziko lokuhlutha, nto leyo ephucula amandla okutya kwezilwanyana. Izifundo ezininzi zibonise ukuba ukufaka idosi ethile yeGABA kwiindawo ezahlukeneyo zobuchopho bezilwanyana kunokukhuthaza kakhulu ukondliwa kwezilwanyana kwaye kunefuthe elixhomekeke kwidosi. Ukongeza iGABA ekutyeni okusisiseko kweehagu ezityebileyo kunokunyusa kakhulu ukutya kweehagu, kwandise ukutyeba, kwaye akunciphisi ukusetyenziswa kweproteni yokutya.

2. Impembelelo yeGABA ekugayweni kwesisu nakwinkqubo ye-Endocrine Njenge-neurotransmitter okanye i-modulator, i-GABA idlala indima ebanzi kwinkqubo ye-peripheral Autonomic nervous system yezilwanyana ezinethambo lomqolo.

3. Impembelelo ye-GABA kwintshukumo yesisu. I-GABA ikhona kakhulu kwindlela yesisu, kwaye ii-GABA immunoreactive nerve fibers okanye ii-positive nerve cells zikhona kwinkqubo yemithambo-luvo nakwi-membrane yendlela yesisu yezilwanyana ezincancisayo, ii-GABA endocrine cells nazo zisasazwa kwi-epithelium ye-Gastric mucosa. I-GABA inempembelelo yokulawula kwiiseli zemisipha egudileyo yesisu, iiseli ze-endocrine kunye neeseli ezingezizo ze-endocrine. I-GABA yangaphandle inempembelelo ebalulekileyo yokuthintela kwiinxalenye zamathumbu ezizimeleyo zeempuku, ebonakaliswa kukunciphisa ukuphumla kunye nokuqiniswa kwe-amplitude yeendawo zamathumbu ezizimeleyo. Le ndlela yokuthintela ye-GABA inokwenzeka ngokuthintela iinkqubo ze-cholinergic kunye/okanye ezingezizo ze-cholinergic zamathumbu, Isebenza ngaphandle kwenkqubo ye-adrenergic; Ingabophelela ngokuzimeleyo kwi-GABA receptor ehambelanayo kwiiseli zemisipha egudileyo yamathumbu.

4. I-GABA ilawula imetabolism yezilwanyana. I-GABA inokuba nemiphumo eyahlukeneyo kwinkqubo yesisu njengehomoni yendawo, njengakwii-gland ezithile kunye neehomoni ze-endocrine. Phantsi kweemeko ze-in vitro, i-GABA inokukhuthaza ukukhutshwa kwehomoni yokukhula ngokusebenzisa i-GABA receptor esiswini. Ihomoni yokukhula kwezilwanyana inokukhuthaza ukwenziwa kwee-peptides ezithile kwisibindi (ezifana ne-IGF-1), inyuse izinga le-metabolic yeeseli zemisipha, inyuse izinga lokukhula kunye nezinga lokuguqulwa kokutya kwezilwanyana, Kwangaxeshanye, ikwatshintshe ukusasazwa kwezondlo zokutya emzimbeni wesilwanyana; Kunokucingelwa ukuba isiphumo sokukhuthaza ukukhula kwe-GABA sinokunxulunyaniswa nokulawula kwayo umsebenzi wehomoni yokukhula ngokuchaphazela umsebenzi wenkqubo ye-Endocrine yemithambo-luvo.