Igama :γ- aminobutyric acid(GABA）

Inombolo yeCAS: 56-12-2

Izithethantonye: 4-Ai-minobutyric acid; Ammonia butyric acid;Pipecolic acid.

1. Impembelelo yeGABA ekutyisweni kwezilwanyana kufuneka ihlale ingaguquguquki kwixesha elithile. Ukutya okutyiwayo kunxulumene kakhulu nokusebenza kwemveliso yemfuyo kunye neenkukhu. Njengomsebenzi wokuziphatha onzima, ukondla kulawulwa ikakhulu yinkqubo ye-nervous central. Iziko lokuhlutha (i-Ventromedial nucleus ye-hypothalamus) kunye neziko lokutya (indawo ye-hypothalamus esecaleni) ngabalawuli bezilwanyana.

Iziko elisisiseko lokutya i-GABA inokubangela ukutya kwezilwanyana ngokuthintela umsebenzi weziko lokuhlutha, ukuphucula amandla okutya kwezilwanyana. Uphononongo oluninzi lubonise ukuba ukutofa uluhlu lwedosi ethile ye-GABA kwimimandla eyahlukeneyo yobuchopho bezilwanyana kunokukhuthaza kakhulu ukondla izilwanyana kwaye kube nesiphumo esixhomekeke kwithamo. Ukongeza i-GABA kukutya okusisiseko kweehagu ezityetyisiweyo kunokunyusa kakhulu ukutya kweehagu, ukonyusa ubunzima, kwaye kunganciphisi ukusetyenziswa kweprotheyini yokutya.

2. Umphumo we-GABA kwi-gastrointestinal digestion kunye ne-Endocrine inkqubo Njenge-neurotransmitter okanye i-modulator, i-GABA idlala indima ebanzi kwi-peripheral Autonomic nervous system of vertebrates.

3. Impembelelo ye-GABA kwi-motility yesisu. I-GABA ikhona ngokubanzi kwi-gastrointestinal tract, kwaye i-GABA i-immunoreactive nerve fibers okanye iiseli ze-nerve ezintle zikhona kwi-nervous system kunye ne-membrane ye-mammalian gastrointestinal tract, iiseli ze-GABA ze-endocrine nazo zisasazwa kwi-epithelium ye-Gastric mucosa. I-GABA inefuthe lokulawula kwiiseli ze-muscle ezigudileyo zesisu, iiseli ze-endocrine kunye neeseli ezingezona ze-endocrine. I-GABA ye-Exogenous inempembelelo ebalulekileyo yokuthintela kumacandelo e-intestinal angasese eegundane, ezibonakaliswa ekuphumleni kunye nokunciphisa i-contraction amplitude yamacandelo angasese amathumbu. Le ndlela yokuthintela ye-GABA kungenzeka ukuba ibe ngokuthintela inkqubo ye-cholinergic kunye / okanye i-noncholinergic yamathumbu, Ukusebenza ngaphandle kwenkqubo ye-adrenergic; Isenokuzibophelela ngokuzimeleyo kwi-receptor ye-GABA ehambelanayo kwiiseli ze-intestinal smooth muscle.

4. I-GABA ilawula i-metabolism yezilwanyana. I-GABA ingaba neempembelelo ezininzi kwiinkqubo zesisu njengehomoni yendawo, njengamadlala athile kunye namahomoni e-endocrine. Ngaphantsi kweemeko ze-in vitro, i-GABA inokuvuselela ukukhuselwa kwehomoni yokukhula ngokuvula i-GABA receptor esiswini. I-hormone yokukhula kwezilwanyana inokukhuthaza ukuhlanganiswa kwamanye ama-peptides kwisibindi (njenge-IGF-1), ukwandisa izinga le-metabolism yeeseli ze-muscle, ukwandisa izinga lokukhula kunye nesantya sokuguqulwa kokutya kwezilwanyana, Kwangaxeshanye, iphinde yatshintsha ukuhanjiswa kwezondlo zokutya emzimbeni wezilwanyana; Inokucingelwa ukuba impembelelo yokukhuthaza ukukhula kwe-GABA inokuhambelana nokulawulwa kwayo komsebenzi we-hormone yokukhula ngokuchaphazela umsebenzi we-nervous Endocrine system.