Njengomanduleli we-butyric acid,i-tributyl glyceridesisongezelelo se-butyric acid esibalaseleyo esineempawu zomzimba nezekhemikhali ezizinzileyo, ukhuseleko kunye neziphumo ebezingalindelekanga ezingenabungozi. Ayisombululi nje kuphela ingxaki yokuba i-butyric acid inuka kakubi kwaye itshintsha lula, kodwa ikwasombulula ingxaki yokuba i-butyric acid kunzima ukuyidibanisa ngqo esiswini nasemathunjini. Inamathuba amaninzi okusetyenziswa kwicandelo lesondlo sezilwanyana. Njengesongezelelo sokondla,i-tributyl glycerideinokusebenza ngokuthe ngqo kwindlela yokugaya ukutya yezilwanyana, inike amandla kwindlela yokugaya ukutya yezilwanyana, iphucule impilo yamathumbu ezilwanyana, kwaye ilawule ukukhula kwezilwanyana kunye nemeko yazo yempilo.

1. Ukuphucula ukusebenza kokukhula

Ukongezwa kwei-tributyl glycerideUkutya kuye kwasetyenziswa kakhulu ekuveliseni zonke iintlobo zezilwanyana. Ukongeza isixa esifanelekileyo se-tributyl glyceride ekutyeni kunokunyusa umyinge wokunyuka kobunzima bemihla ngemihla bezilwanyana ezivavanywayo, ukunciphisa umlinganiselo wokutya ukuya kobunzima, kunye nokuphucula ukusebenza kokukhula kwezilwanyana. Isixa esongeziweyo yi-0.075% ~ 0.250%.

2. Ukuphucula impilo yamathumbu

I-TributyrinIngadlala indima ebalulekileyo kwimpilo yamathumbu esilwanyana ngokuphucula indlela amathumbu asebenza ngayo kunye nolwakhiwo lwawo, ilawule ulungelelwaniso lwezityalo zamathumbu, iphucule umqobo wamathumbu kunye namandla e-antioxidant. Olu phononongo lufumanise ukuba ukongeza i-TB ekutyeni kunokunyusa ukubonakaliswa kweproteni ye-intestinal tight junction, kukhuthaze uphuhliso lwe-intestinal mucosa, kuphucule ukugaywa kwezondlo zokutya, kuphucule amandla e-antioxidant, kunciphise umxholo weebhaktheriya eziyingozi kwindlela yamathumbu kwaye kunyuse umxholo weebhaktheriya eziluncedo, kukhuthaze uphuhliso lwamathumbu ezilwanyana, kwaye kuphucule impilo yamathumbu ezilwanyana.

Kukho izifundo ezithile ezibonise ukuba ukongezwa kwe-TB ekutyeni kunokuphucula kakhulu ukugaywa kweproteni ekrwada, amafutha akrwada kunye namandla eehagu ezilunyulweyo, kwaye ukugaywa kwezondlo zokutya kunxulumene kakhulu nempilo yamathumbu ezilwanyana. Kuyabonakala ukuba i-TB ikhuthaza ukufunxwa kunye nokugaywa kwezondlo emathunjini.

Ukongezwa kwei-tributyl glycerideinokunyusa kakhulu ukuphakama kwe-villus kunye nexabiso le-V/C lendlela yamathumbu yamantshontsho okulumla, inciphise umxholo we-MDA kunye ne-hydrogen peroxide kwi-jejunum, iphucule ukusebenza kwe-mitochondrial, inciphise uxinzelelo lwe-oxidative kumantshontsho, kwaye ikhuthaze uphuhliso lwamathumbu.

Ukongezwa kwe-microencapsulated tributyl glyceride kunokunyusa kakhulu ubude be-villus ye-duodenum kunye ne-jejunum, kwandise umxholo webhaktheriya ye-lactic acid kwi-cecum kwaye kunciphise umxholo we-Escherichia coli, kwenze ngcono ulwakhiwo lwezityalo zamathumbu zeenkukhu, kwaye isiphumo se-microencapsulated TB singcono kunese-liquid TB. Ngenxa yendima ekhethekileyo ye-rumen kwizilwanyana ezirhubuluzayo, zimbalwa iingxelo malunga nemiphumo ye-tributyl glyceride kwizilwanyana ezirhubuluzayo.

Njengesixhobo samandla emathunjini, i-tributyrin inokuphucula ngempumelelo kwaye ilungise imo kunye nolwakhiwo lwamathumbu, iphucule ukugaya kunye namandla okufunxa amathumbu, ikhuthaze ukwanda kweebhaktheriya eziluncedo emathunjini, iphucule ulwakhiwo lwezityalo zamathumbu, inciphise impendulo yoxinzelelo lwe-oxidative kwizilwanyana, ikhuthaze uphuhliso lwamathumbu ezilwanyana, kwaye iqinisekise impilo yomzimba.

Olu phononongo lufumanise ukuba ukongezwa kwe-compound yei-tributyrinkunye neoyile ye-oregano okanye i-methyl salicylate ekutyeni kwamantshontsho eehagu ancancisiweyo inokunyusa ixabiso le-V/C yamathumbu, iphucule indlela amathumbu eehagu ancancisiweyo ngayo, inyuse kakhulu ubuninzi beFirmicutes, inciphise ubuninzi beProteus, i-Actinobacillus, i-Escherichia coli, njl.njl., itshintshe isakhiwo sezityalo zamathumbu kunye ne-metabolites, nto leyo eluncedo kwimpilo yamathumbu amantshontsho eehagu ancancisiweyo, kwaye inokuthatha indawo yee-antibiotics ekusetyenzisweni kwamantshontsho eehagu ancancisiweyo.

Nje,i-tributyrinInemisebenzi eyahlukeneyo yebhayoloji efana nokubonelela ngamandla emzimbeni, ukugcina ukuqina kwamathumbu, ukulawula ulwakhiwo lwezityalo zamathumbu, ukuthatha inxaxheba kwiimpendulo zomzimba kunye ne-metabolic, njl. Ingakhuthaza uphuhliso lwamathumbu ezilwanyana kwaye iphucule ukusebenza kokukhula kwezilwanyana. I-Glyceryl tributylate inokubola yi-pancreatic lipase emathunjini ukuze ivelise i-butyric acid kunye ne-glycerol, engasetyenziswa njengomthombo osebenzayo we-butyric acid emathunjini ezilwanyana. Ayisombululi nje kuphela ingxaki yokuba i-butyric acid kunzima ukuyongeza ekutyeni ngenxa yevumba layo kunye nokuguquguquka kwayo, kodwa ikwasombulula ingxaki yokuba i-butyric acid kunzima ukungena emathunjini ngesisu. Yindlela yokubulala iintsholongwane esebenzayo kakhulu, ekhuselekileyo kwaye eluhlaza.

Nangona kunjalo, uphando olukhoyo ngoku malunga nokusetyenziswa kwei-tributyl glyceridekwisondlo sezilwanyana zimbalwa kakhulu, kwaye uphando malunga nobungakanani, ixesha, uhlobo kunye nokudibana kwesifo sephepha kunye nezinye izondlo alukho kangako. Ukuqinisa ukusetyenziswa kwe-tributyl glyceride kwimveliso yezilwanyana akunakubonelela kuphela ngeendlela ezintsha zokhathalelo lwempilo yezilwanyana kunye nokuthintela izifo, kodwa kukwanegalelo elikhulu ekuphuhlisweni kwezinto ezithatha indawo ye-antibiotic, kunye namathuba amaninzi okusetyenziswa.